PlGF is known to be responsible for angiogenesis in the placenta and actively binds to VEGFR-1 (vascular endothelial growth factor-1 receptor-1) and its soluble variant sFLT-1 (soluble fms-like tyrosine kinase-1), which is the key molecule in the pathogenesis of preeclampsia, primarily due to endothelial damage [31]. This evidence concerns the gene PGF and preeclampsia.