TP53 and lung cancer: UBCH10 in lung cancer is also related to tumor differentiation and patient survival, and UBCH10 can lead to P53 and EGFR gene mutations, resulting in loss of tumor inhibitory effect of P53 gene and enhancement of growth promoting effect of EGFR, while the proliferation of lung cancer cells and drug resistance of chemotherapy drugs are weakened after UBCH10 gene silencing (14, 15).