Whereas CellphoneDB (50) predicts a highly dense network of 720 out of 729 (98.8%) of possible interactions, involving nearly all pairwise combinations of cell-states, Calligraphy identified a sparser, more interpretable network of potential neoplasia-specific interactions between the Kras-mutant epithelium and the immune environment (5.6% of possible interactions, Fig. S11B,C and Table S7). This evidence concerns the gene KRAS and neoplasm.