Specifically, we profiled pancreatic epithelial cells from healthy pancreas (N1) undergoing reversible metaplasia associated with normal regeneration after injury (N1→N2), and the metaplasia-neoplasia-adenocarcinoma sequence that initiates PDAC in the presence of mutant Kras (K1→K6) (Figs. 1A, S1A and Table S1). Here, KRAS is linked to neoplasm.