Il33 is expressed during pancreatitis by a small subset (4%) of TFF1/ANXA10+Kras-mutant Gastric module-expressing epithelial cells and is predicted to initiate signaling to Tregs and ILCs (Module T8) by binding with its cognate receptor Il1rl1 and co-receptor Il1rap (Figs. 5B and S12A–D). Here, IL1RL1 is linked to pancreatitis.