BAK1 and B-cell chronic lymphocytic leukemia: Our results demonstrated that only the inhibitors of cyclophilin D (NIM811 and cyclosporin A [CspA]) that are known to mediate mPTP induction in the mitochondria were able to block the cytotoxicity induced by DT-061 in both WT as well as Bax/Bak-DKO MEC1 CLL cells (Supplemental Figure 6).