Similarly, CRISPR activation–mediated (CRISPRa-mediated) SELENOP overexpression in RKO cells (Figure 6E) or MC38 (mouse colon adenocarcinoma) cells (Figure 6G) augmented WNT3A-induced TOPFlash activity (Figure 6F, Figure 6H). Here, WNT3A is linked to colon adenocarcinoma.