Moreover, in tail-vein models of lung metastasis in nude mice, fewer metastatic foci were observed in tissue sections of the lungs in PKO cells infected with lentiviral sgS100A11 (Figure 5, H and I), illustrating that the lung metastatic potential of PCK1-deficient hepatoma cells could be facilitated by S100A11. Here, PCK1 is linked to hepatocellular carcinoma.