On the contrary, CCN1 is upregulated during hepatic injury acting as an inhibitor of liver fibrosis by triggering induction of reactive oxygen species, cellular senescence, apoptosis and reduced TGF-β signaling in activated HSC and portal fibroblasts (Kim et al. 2013; Borkham-Kamphorst et al. 2014). This evidence concerns the gene CCN1 and Hepatic fibrosis.