In hepatic fibrosis, CCN3 is increased expressed and mainly found in non-parenchymal cells, stimulate the migration of HSC and induce hepatocyte apoptosis, while the suppression of CCN3 enhanced expression of profibrotic marker proteins in primary HSC (Borkham-Kamphorst et al. 2012a, 2012b). Here, CCN3 is linked to Hepatic fibrosis.