He is given a trial of dopamine agonists but is unable to tolerate these and is subjected to trans-sphenoidal pituitary surgery: in this case, the tumor is immunonegative for PIT1 and prolactin, but stains for SF1, GATA3, and focally for LH, and the diagnosis is changed to “gonadotroph tumor.” He had disconnection hyperprolactinemia, and this necessitates a different follow-up strategy. The gene discussed is PLOD1; the disease is neoplasm.