When these markers were similarly evaluated in the CDAA-HFAT fed CreAlb group (α-SMA IHC p = 0.8, picrosirius red p = 0.99), no significant difference could be appreciated in the modulation of NASH-related HSC activation and fibrosis deposition when compared to the WT group (Supp. The gene discussed is ACTA1; the disease is metabolic dysfunction-associated steatohepatitis.