When merging these signals, a significant overlap between CHI3L1 and Ly6C+ macrophages was observed, while a lack of co-localization could be seen in resident CLEC4F+ macrophages, suggesting that infiltrating activated Ly6C+ macrophages are the main source of CHI3L1 during NASH development, rather than the resident Kupffer cells. The gene discussed is CLEC4F; the disease is metabolic dysfunction-associated steatohepatitis.