MC38 and MC38-PD-L1 KO tumor-bearing mice were treated as described in Fig. 5B. Consistent with our previous results (Figs. 3D and 4D), MC38 tumor-bearing mice treated with docetaxel + NHS-IL-12 in combination had improved overall survival compared to the untreated group (purple line; p < 0.0001; Fig. 5C). The gene discussed is CD274; the disease is neoplasm.