The quantitative results indicated that the proportion of CD4+ T cells, CD8+ T + cells, activated dendritic cells, CD56 bright natural killer cells, eosinophils, MDSC, macrophages, gamma delta T cells, mast cells, neutrophils, regulatory T cells and type 17/12 T helper cells were elevated remarkably in the RA group in comparison with the HC group. The gene discussed is NCAM1; the disease is rheumatoid arthritis.