SETD2-1740 and SETD2-LLS NDD cohorts: In contrast to the SETD1A NDD individuals, a combined analysis of the methylation profiles in 10 individuals with SETD2 variants to controls (n = 64) identified 135 significant DMPs (17 hypomethylated and 118 hypermethylated for SETD2-1740, 81 hypomethylated and 54 hypermethylated for SETD2-LLS) with 1 DMB and 5 CpG islands (Supplementary Material, Fig. S2). The gene discussed is SETD1A; the disease is Neurodevelopmental delay.