Interestingly, the methylation episignatures of LLS individuals and of other non-imprinting epigenetic disorders associated with congenital overgrowth such as Sotos syndrome and DNMT3A-overgrowth syndrome (Tatton-Brown-Rahman syndrome; MIM:615879) demonstrate predominant hypomethylation (36,37). This evidence concerns the gene DNMT3A and overgrowth syndrome.