SETD2 and hereditary clear cell renal cell carcinoma: Furthermore, (a) SETD2 is frequently mutated in a range of human cancers, with the highest frequencies in mesothelioma, endometrial cancer and renal cell carcinoma but somatic SETD2 mutations also occur in sarcoma and glioblastoma multiforme (TCGA PanCancer Atlas) and (b) SETD2 has been implicated in the repair of DNA double-strand breaks (41).