DNMT3A and Tatton-Brown-Rahman overgrowth syndrome: Interestingly, the methylation episignatures of LLS individuals and of other non-imprinting epigenetic disorders associated with congenital overgrowth such as Sotos syndrome and DNMT3A-overgrowth syndrome (Tatton-Brown-Rahman syndrome; MIM:615879) demonstrate predominant hypomethylation (36,37).