In renal fibrosis, elevated Yap was identified in renal fibroblasts after unilateral ureteral obstruction (UUO), a mouse model of renal fibrosis, and inactivation of Yap1/Wwtr1 reduced the expression of fibronectin, collagen, and α-SMA Liang et al., 2017. This evidence concerns the gene FN1 and Ureteral obstruction.