EIF2AK3 and central nervous system cancer: However, miR‐19a expression remained unchanged in IDHwt cells even with Tu treatment (Figure 7A), reminiscent of the characteristics of IDHwt glioma cells on resistance to ERS, as previously reported.[32] To identify which UPR signaling branch induces the miR‐19a/LDLR axis in IDHmt glioma cells, we conducted GSEA using the published scRNA‐seq data and found enriched PERK activation‐mediated UPR signaling in IDHmt glioma cells (Figure 7B).