PTEN and central nervous system cancer: To illustrate the core impact of IDH mutation on tumoral cholesterol metabolism and to set it apart from various confounding genetic vulnerabilities in clinical samples, we compared our previous mouse models of intrinsic gliomas initiated by the inactivation of tumor suppressor genes Pten and Tp53 in forebrain progenitors, with or without expression of an additional human IDH1R132H mutation.[32] The IDH mutation is the sole identifier of the resulting murine glioma‐initiating cells (mGICs), which were isolated from the mouse brain parenchyma (Figure 4A).