Glioma, particularly its highest grade, GBM, is known to be an “immunologically cold” tumor with a hyporesponsive and exhausted state of tumor‐infiltrating lymphocyte (TIL).[49, 50, 51] Our analysis of patient samples, consistent with previous reports, showed minimal CD8+ T cell infiltration into gliomas, with no significant difference observed between IDHmt and IDHwt gliomas (Figure S10A,B, Supporting Information, IDHmt: IDHwt = 5: 5, p = 0.6548). The gene discussed is CD8A; the disease is central nervous system cancer.