To this end, we conducted immunohistochemistry (IHC) staining on the GL261 syngeneic gliomas samples and observed that GAMs in IDHmt gliomas exhibited high expression levels of CD86, a marker of M1‐like polarization, but extremely low levels of CD163, a marker of M2‐like polarization, relative to GAMs in IDHwt gliomas (Figure 1H,I). Here, CD86 is linked to central nervous system cancer.