LDLR and central nervous system cancer: We found that IDHmt cells exhibited downregulation of three key cholesterol synthesis enzymes (HMGCR, HMGC1, and DHCR24), concomitant with augmented expression of cholesterol efflux regulator ABCA1 and reduced expression of the cholesterol uptake gene, LDLR, compared to IDHwt glioma cells (Figure S6C, Supporting Information).