Further, to determine the involvement of IDHmt in regulating cholesterol transport, specifically influx and efflux, through PERK signaling, we utilized small‐molecule compounds, such as CCT020312 (a PERK agonist) and ISRIB (a PERK antagonist), to modify the cholesterol transport in glioma cells. The gene discussed is EIF2AK3; the disease is central nervous system cancer.