We also found that IDHmt gliomas had a higher proportion of GAMs with an M1‐like phenotype (IDHmt: IDHwt = 90.62%: 75.86%) (Figure S1B, Supporting Information), as supported by an augmented proinflammatory signaling consisting of GAM‐associated cytokines and receptors, such as TNF, TLR2, and TNFRSF1B (Figure S1C, Supporting Information). Here, TNF is linked to central nervous system cancer.