Several key regulatory enzymes involved in cholesterol metabolism are located in the ER, where cholesterol production takes place.[45] IDH mutation can disrupt ER homeostasis, leading to the unfolded protein response (UPR) and metabolic changes in glioma cells.[32, 33, 34] Thus, we investigated whether IDH mutation regulates the miR‐19a/LDLR axis via ERS/UPR signaling. This evidence concerns the gene IDH1 and glioma.