However, miR‐19a expression remained unchanged in IDHwt cells even with Tu treatment (Figure 7A), reminiscent of the characteristics of IDHwt glioma cells on resistance to ERS, as previously reported.[32] To identify which UPR signaling branch induces the miR‐19a/LDLR axis in IDHmt glioma cells, we conducted GSEA using the published scRNA‐seq data and found enriched PERK activation‐mediated UPR signaling in IDHmt glioma cells (Figure 7B). Here, LDLR is linked to central nervous system cancer.