To better understand the mechanistic link between miRNAs and cholesterol metabolism in IDHmt versus IDHwt gliomas, we first compared miRNA expression profiles of astrocytoma patient‐derived glioma‐initiating cells (pdGICs) with or without IDH mutations (IDHmt: IDHwt = 2: 4) (Figure 5A). Here, IDH1 is linked to central nervous system cancer.