They electroporated Cas9 and sgRNA targeting p53, an upregulated modulator of apoptosis (PUMA), cyclin E1 (CcnE1), and K (lysine) acetyltransferase 5 (KAT5) into exosomes derived from the LX‐2 cell line and treated acute liver injury, chronic liver fibrosis, and hepatocellular carcinoma mouse models. Here, CCNE1 is linked to hepatocellular carcinoma.