Intracranial tumor‐infiltrating T‐cells in the GIFT7‐TVax group showed reduced CD4+ T‐cell exhaustion (VC vs GIFT‐7: CD3+/CD4+/PD1+/Lag3+: 11.8% Vs 4.4% p < 0.001) (Figure 2e), increased CD8+ cytotoxicity (VC vs GIFT‐7: CD8 + GranB+: 3.7% Vs 10.8% p < 0.01) (Figure 2f), and increased activation (Jin et al., 2010) within the CD8+ compartment (VC vs GIFT‐7: CD3+/CD8+/PD1+/Lag3–57.7% Vs 83.6% p < 0.001) (Figure 2g). This evidence concerns the gene CD4 and neoplasm.