The CCDC92-ZNF664 locus has also been implicated in many different metabolic disorders, including type-2 diabetes and coronary heart disease (Figure 5).24 The sentinel sQTL SNP at this colocalized locus has been associated with variation in total cholesterol, metabolic syndrome, and waist circumference in previous studies. The gene discussed is ZNF664; the disease is type 2 diabetes mellitus.