SNPs in PGS1 are associated with changes in triglyceride levels during diabetes treatment.22 Interestingly, the second SNP in the credible set for this sQTL falls within the canonical splice site of the splicing event (as demonstrated by the red arrow in Figure 4D).23 Furthermore, the differentially spliced intron for PGS1 is associated with a transcript that is predicted to undergo nonsense-mediated decay (PGS1-002), suggesting that the splicing event will have significant impact on levels of functional protein. Here, PGS1 is linked to diabetes mellitus.