Univariate logistic regression analysis demonstrated that factors such as age, HDL‐C, FFAs, HbA1c, FCP, 2‐h‐PCP, urinary protein, FT3, β‐CTX, lower limb atherosclerosis, carotid atherosclerosis, proportion of 10‐year high ASCVD risk, duration of intensive insulin therapy, and time for FPG to reach target were statistically significant (all, p < .05). The gene discussed is INS; the disease is carotid atherosclerosis.