At a minimum, MGPT focused on hereditary gastric cancer risk should include genes associated with HDGC (CDH1 and CTNNA1), LS (MLH1, MSH2, EPCAM, MSH6, PMS2), FAP (APC), PJS (STK11), JPS (SMAD4 and BMPR1A), and LFS (TP53). The gene discussed is SMAD4; the disease is gastric cancer.