To unbiasedly assess whether FGFR2‐mutant ECs display increased EGFR activity resulting from aberrant FGFR2‐associated ADAM17, we comparatively profiled the transcriptomes of 464 endometrial tumours (402 The Cancer Genome Atlas [TCGA] and 62 the University of Iowa), including 53 FGFR2‐mutant tumours (25 S252W, 11 K310R and 17 N550K‐mutants) and 411 FGFR2‐WT tumours (Figure 3A, Figure S2A,B). Here, EGFR is linked to endometrium neoplasm.