EDN1 and pulmonary edema: Although previous studies have demonstrated ET-1, soluble kinase domain receptor (sKDR), Corin, angiotensin-converting enzyme, natriuretic peptide (NPs), high-sensitivity troponin T (hs-cTnT), metabolites (C8-neuramide, sphingosine, and glutamine), and sulfotransferase 1A1 (SULT1A1) as diagnostic markers for high altitude pulmonary edema [6, 14, 15].