Glioma cells also express molecules that suppress the lytic action of lymphocytes, such us FAS ligand (FasL) [109] PD-L1 and PD-L2 [63].Specifically, the immunological synapse generated by the PD-1/PD-L1 interaction is a key point and important object of study today. The gene discussed is PDCD1; the disease is central nervous system cancer.