In the TME, post-synaptic neurons support the progression of gliomas by promoting the transition of mitogenic to neoplastic cells through the upregulation of neuroligin-3 (NLGN3), inducing a phosphoinositide 3-kinase (PI3K) signaling-mediated proliferative activity in glioma cells [73]. The gene discussed is NLGN3; the disease is central nervous system cancer.