To begin to dissect the potential consequences of the expression of intact and functional L1Hs loci in SLE neutrophils, we first measured by real-time PCR a commonly used set of type I interferon-inducible genes (IFI6, IFI27, IFI44, and IFI44L) in both neutrophils and lymphocytes from SLE patients and heathy volunteers. Here, IFI6 is linked to systemic lupus erythematosus.