A 4-h treatment of SLE neutrophils from three independent donors with the combination of the two reverse transcriptase inhibitors, emtricitabine and tenofovir alafenamide, which are known to be effective against ORF2p [50, 51], resulted in a decline in the ISGs, as well as reduced IFNB expression, compared to neutrophils treated for the same time with medium alone (Fig. 5E and F). Here, IFNB1 is linked to systemic lupus erythematosus.