PACC1 and Alzheimer disease: Although the expressions of the representative microglial activation marker genes, such as AIF1, CD68, and LGALS3, were not altered, those of microglial-specific genes such as BCO2, CAPN3, small G-protein-associated genes (RASGRP3 and RAPGEF5), PACC1, also known as TMEM206, and P2RX7, were significantly decreased in AD precunei compared with controls.