In this context, STAT1 binds to a conserved element within the first intron of NAMPT, termed NAMPT-Regulatory Element-1 (NRE1), and enhances its expression, thus driving aerobic glycolysis and initiating expressions of a subset of inflammatory genes in the tumor-associated macrophages stimulated with IFN-γ [91]. The gene discussed is NAMPT; the disease is neoplasm.