SOX2 and neoplasm: Similarly, it has been reported that the FGF/FGFR system enhanced stemness by increasing stability and nuclear localization of SOX2 in pancreatic cancer [28], promoted the reversion of tumor cells to an undifferentiated, stem-like state in glioblastoma [56], and regulated CSCs through ERK signaling in a model of esophageal squamous cell carcinoma [57].