Although, studies have reported variants in CRB1, PDE6A, PDE6B, RP1, TULP1, CLRN1, MERTK and CNGA1 causing non-syndromic RP and MYO7A, USH2A, CDH23, USH1H, PCDH15 genes are responsible for USH phenotypes in families of Pakistani origin [8, 21–28]. This evidence concerns the gene CRB1 and retinitis pigmentosa 1.