A novel PDE6C frameshift deletion variant NM_006204.4:c.480delG in exon 1 and a rare TULP1 nonsense variant NM_003322.6:c.238 C > T in exon 4, were observed to segregate with progressive cone dystrophy and non-syndromic RP respectively in family 3. This evidence concerns the gene TULP1 and retinitis pigmentosa 1.