In addition, the knockdown of JMJD2A resulted in significantly higher miR-34a and β3-Tubulin expression and lower STMN1 expression compared with the shNC group; consistent with the previously validated effects of the miR-34a/STMN1/β3-Tubulin axis on prostate cancer cells. This evidence concerns the gene STMN1 and Familial prostate cancer.