CLOCK and cancer: Six metastatic cancer types also displayed more mutations from the clock-like mutational processes, including five cancer types (diffuse large B cell lymphoma, breast, prostate, pancreatic neuroendocrine and kidney renal clear cell carcinomas) that exhibited an increased SBS1 contribution and three cancer types (hepatocellular, prostate and thyroid carcinomas) that had an increased SBS5/SBS40 mutation burden.