MAPT and early-onset autosomal dominant Alzheimer disease: As the result, 284 cases with available data of demographics (age, sex and education years), APOE genotypes, plasma biomarkers (Aβ40, Aβ42, P-tau181, T-tau and NfL), brief cognitive test (MMSE) and the results of Aβ-PET were collected, including 97 of CN, 124 of MCI and 63 of Alzheimer’s disease patients.