AP2M1 and frontotemporal dementia: For example, among the genes we found to be expressed across all tissue types (group 1), mutations in AP2M1 have been linked to epilepsy, intellectual developmental disorder, and seizures [58]; among the genes expressed in low levels across tissues (group 2), STH has been associated with frontotemporal dementia and 17q21.31 duplication syndrome [59, 60].