Moreover, four top disease markers, PCSK1N, HNRNPA1, pPLA2G4A, and pLTB4R, are known to be involved in such important PD pathways as neuronal cell death, neuroinflammation, autophagy, and formation of amyloid fibrils (Fig. 3e; see Supplementary Data 8 for more details). This evidence concerns the gene HNRNPA1 and Parkinson disease.