As potential disease markers, HNRNPA1, IDE, and STK11 proteins are shown to be involved in certain pathways that are important in PD progressions, such as protein targeting to peroxisome, AMPK signaling pathway, leukocyte activation, and mRNA splicing (Fig. 3d, see Supplementary Data 7 for protein–protein interactions). This evidence concerns the gene STK11 and Parkinson disease.