CD274 and neoplasm: We applied LILAC and a universal tumor-processing pipeline to establish a comprehensive portrait of GIE events and their positive selection landscape across six different pathways associated with an immune evasion phenotype: the HLA-I locus, the antigen presentation machinery, interferon (IFN)-γ signaling pathway, the programmed cell death ligand 1 (PD-L1) immune checkpoint, the costimulatory signaling by the CD58 receptor and epigenetic immune escape driven by SETDB1 (Fig. 1a and Supplementary Table 1).