IFNG and cancer: The most frequent GIE alteration was partial loss of the HLA-I locus (including both LOH of HLA-I and homozygous deletions of HLA-I genes that were grouped as LOH of HLA-I for simplicity), which was present in 783 (18%) of metastatic and 319 (17%) of primary cancer patients, followed by IFN-γ inactivation (4% in metastatic and 3% in primary) and alterations in the antigen presentation pathway (4% in metastatic and 3% in primary).