BGN and synovial sarcoma: While there is no difference in the expression of Bgn and Dcn in the SGs of healthy and SS control mice, Kiripolsky et al. demonstrated that SS mice displayed increased levels of anti-Bgn and -Dcn autoantibodies relative to healthy controls.36 Thus, emerging evidence suggests that degradation of the SG-ECM and basal lamina may precede (or take place in parallel with) the onset of inflammation, which is widely considered the ultimate cause of SS development.