Sarbecovirus belongs to the Betacoronavirus genus and includes SARS-CoV-2, SARS-CoV, and their-related zoonotic coronaviruses isolated from bats, pangolins, etc., that share common features with SARS-CoV or SARS-CoV-2.36,37 These zoonotic coronaviruses may use multiple ACE2 orthologues for host cell entry and exhibit a similar binding affinity as the SARS-CoV-2 RBD-ACE2 interactions.38–41 Along with viral evolution, these zoonotic coronaviruses may, via cross-species transmission, lead to human infection and a potential pandemic. This evidence concerns the gene ACE2 and infection.