Although anti-RBD nAbs for SARS-CoV-2 or MERS-CoV did not cross-neutralize PDF-2180 or NeoCoV, two broad-spectrum SH-targeted nAbs (e.g., S2P6 and B6) can effectively cross-inhibit PDF-2180, NeoCoV, and NeoCoV-T510F PsVs entry into Bat40ACE2- or human ACE2 cells.68 In addition, the sequence and structure of the helical FP between MERS-CoV and PDF-2180 are highly conserved, suggesting that FP-targeted nAbs may be also effective in preventing the potential PDF-2180 infection.68 The gene discussed is ACE2; the disease is infection.