NR3C1 and Anxiety: Several human studies using neonatal cord blood find that prenatal anxiety [85], maternal exposure to interpartner violence [86], and depressive symptoms [87, 88] are associated with differential methylation patterns in the promoter region of NR3C1. In fact, one recent investigation examining pregnant mothers exposed to chronic stress found that placentas and neonatal cord blood had differential methylation patterns across several genes (i.e., CRH, CRHBP, NR3C1, and FKBP5) shown to regulate the HPA axis [89].