Specifically, we found CpGs in the promoter region (cg01512589 and cg26878949) of PTCH1, a transmembrane protein that suppresses the SHH signaling cascade by inhibiting the oncoprotein SMO14, to be hypermethylated in MPNST-G1 but not in MPNST-G2 (Fig. 3f). The gene discussed is SHH; the disease is malignant peripheral nerve sheath tumor.