It was also found that GPR40 was overexpressed in prostate cancer (PCa) tissue compared with benign prostatic hyperplasia tissue, and OA promoted the aggressive phenotype of PCa cells through FFA1/GPR40, calcium and PI3K/Akt signaling.183 These findings suggest that GPR40 plays a cancer-promoting role. The gene discussed is AKT1; the disease is posterior cortical atrophy.