Its cancer-promoting effects are related to proliferation, migration, angiogenesis, cell adhesion, apoptosis and cell cycle regulation.335–337 The expression and activation of GPR56 can regulate the progression of melanoma by specifically inducing IL-6 production after the dissociation of the N-terminal fragment and the self-activation of the C-terminal fragment, thereby promoting cell migration and invasion.335 The higher level of GPR56 expression in colon cancer patients means a poorer prognosis. The gene discussed is ADGRG1; the disease is melanoma.