Further research shows that GPR56 overexpression accelerates epithelial-mesenchymal transition by activating PI3K/AKT signaling, promoting colorectal cancer (CRC) cell metastasis.276 However, GPR56 could inhibit tumor growth and metastasis.338 Melanoma angiogenesis is inhibited as GPR56 prevents melanoma cells from producing VEGF. This evidence concerns the gene VEGFA and neoplasm.