Of all 97 human cancers, mTORC1 is considered to be up-regulated by approximately 70%.121 It has newly been reported to relate to acute myeloid leukemia,317 subependymal giant cell astrocytoma,318 triple-negative breast cancer319 and pancreatic tumor.320 mTOR has also been found to be used in the treatment of cancers. The gene discussed is MTOR; the disease is cancer.