ACACA and lung cancer: Reducing the expression of acetyl-CoA carboxylase 1 (ACC1) increases the global histone acetylation and gene expression by reducing FA synthesis,283 and low-potency ACC1 inhibitor TOFA resulted in tumor regression in MYC-induced renal tumors,284 at the same time, ND-646, a nanomolar inhibitor of ACC1, inhibits tumor fatty acid synthesis and tumor growth of lung cancer in vivo.285,286 However, no clinical trials about them have been conducted.