Sp1 is O-GlcNAcylated, and at least one O-GlcNAc site is associated with its stability.58 Therefore, Hyperglycemia and high glucose increase O-GlcNAcylation of Sp1, thereby promoting tumor cell metabolism and survival.59 Elevated glucose levels enhance the transcriptional activity of at least two members of the NF-kB family, p65 and c-Rel, via O-GlcNAcylation modification. This evidence concerns the gene NFKB1 and neoplasm.