Prednisone’s bacterial side chain cleavage product 1,4-androstadiene-3,11,17-trione can interact with androgen receptors to contribute to the expression and function of downstream targets, showing pro-proliferation function in prostate cancer cells, but the specific proliferative mechanism needs further study.201 Urolithin A destroys the expression and function of Rac family small GTPase 1 (Rac1) and protein activated kinase 1 (Pak1). This evidence concerns the gene RAC1 and prostate carcinoma.