Reducing the expression of acetyl-CoA carboxylase 1 (ACC1) increases the global histone acetylation and gene expression by reducing FA synthesis,283 and low-potency ACC1 inhibitor TOFA resulted in tumor regression in MYC-induced renal tumors,284 at the same time, ND-646, a nanomolar inhibitor of ACC1, inhibits tumor fatty acid synthesis and tumor growth of lung cancer in vivo.285,286 However, no clinical trials about them have been conducted. The gene discussed is ACACA; the disease is neoplasm.