NFKB1 and cancer: The NF-kB pathway is known to be associated with the Hexosamine Biosynthetic Pathway, which has been shown to promote the growth of tumor cells.60 Similar to its role in regulating NF-kB, high glucose conditions increase the activity of the β-catenin pathway, amplifying the response of different human cancer cells to Wnt through O-GlcNAcylation.61 O-GlcNAc has been found to stimulate Yes-associated protein (YAP) function, which plays a crucial role in tumorigenesis.