CDKN1A and colonic neoplasm: It is found that it can induce changes in protein expression of cell cycle regulators (CDK4, CDK6, cyclin D1, cyclin E) and CDKs inhibitors (p21 Waf1/Cip1, p27 Kip1), then inhibit proliferation and mitochondrial activity in colon cancer HT-29 and LS-180 cells, as well as decrease DNA synthesis.364 Cadaverine is a downstream product of lysine.