FFAR2 and colorectal adenocarcinoma: The expression of GPR43 is lost in human colon cancer cell lines and sharply down-regulated in colorectal adenocarcinoma.158 GPR43 deficiency promotes the development of both colon adenoma in ApcMin + DSS (dextran sulfate sodium) mice and the adenomas to adenocarcinoma in azoxymethane/ dextran sulfate sodium (AOM/DSS) mice.159 GPR43 deficiency or lacking of fiber in diet can lead to increased recruitment and migration of neutrophils,160 which cause inflammation.