DMU-214 inhibition of GPR56 expression, the decrease of GPR56 expression triggered by DMU-214 was accompanied by the inhibition of SKOV-3 cell motility.276 The ginseng metabolite protopanaxadiol (PPD) can induce the expression of BH3-only proteins Puma and Noxa, thereby promoting the death of colorectal cancer cells, and also enhancing the anti-cancer effect of fluorouracil (5-FU). The gene discussed is ADGRG1; the disease is colorectal cancer.