AKT1 and melanoma: Further research shows that GPR56 overexpression accelerates epithelial-mesenchymal transition by activating PI3K/AKT signaling, promoting colorectal cancer (CRC) cell metastasis.276 However, GPR56 could inhibit tumor growth and metastasis.338 Melanoma angiogenesis is inhibited as GPR56 prevents melanoma cells from producing VEGF.