Further, other shared enriched genes included RABEP2 involved in disrupted vesicle trafficking leading to abnormal protein aggregation30; CD19 and LAT with links to peripheral inflammation in PD31,32; and SPNS1, which has been associated with autophagic dysfunction in animal models of PD and in brains of individuals who were diagnosed with PD33. Here, SPNS1 is linked to Parkinson disease.