When we examined the Cd11b+Cd45.2+ fraction of cells in the P0 tumor, we noted a Trem2+ percentage anywhere from 50-75%, but when we looked at the Cd11b+Cd45.2+ in the P1 or P2 tumors, we noticed a significant increase relative to the quantity of Trem2-Cd45.2+ cells (Fig. 8f, g and Supplementary Fig. 7b). The gene discussed is ITGAM; the disease is neoplasm.