Cluster III contains also several proteins from the PF01841 (Transglut_core) family: seven TGM acetyltransferases playing roles in cell signaling, cytoskeleton organization, muscle contraction, inflammation (212, 213), factor XIII stabilizing the fibrin clot (214), KY peptidase is important for muscle functioning (215), and catalytically inactive EPB42 related to hereditary spherocytosis, a chronic nonimmune hemolytic anemia (216). The gene discussed is EPB42; the disease is hereditary spherocytosis.