FOXP3 and type 1 diabetes mellitus: For the FOXP3 trans-score, for instance, the information for discrimination (calculated as half the square of the standardized log odds ratio) is 0.026 natural log units, which is about 2% of the non-HLA genetic information for discrimination for T1D, assuming that the total genetic information for discrimination is about 2.5 (equivalent to sibling recurrence risk ratio of 12) and that half of this is contributed by genes outside the HLA region.