One of the proteins in MAM was found to be WFS1 (Wolfram syndrome 1; also called wolframin) (Delprat et al., 2018; Horner et al., 2015; La Morgia et al., 2020; Poston et al., 2013; Zhang et al., 2011), loss of function of which causes a rare, early-onset neurodegenerative disorder called Wolfram syndrome (WS) with no effective cure (Abreu and Urano, 2019; Barrett et al., 1995; Inoue et al., 1998). The gene discussed is WFS1; the disease is Wolfram syndrome.