Llamas were immunized with (i) rec α-syn (140 amino acids) (for the anti–α-syn sdAbs) as per protocol in table S1 (see Materials and Methods) or (ii) full-length recombinant longest isoform (2N4R) of rec tau for the first five immunizations and then with enriched paired helical filament (PHF) tau isolated from human tauopathy brain for the last two immunizations (for the anti-tau sdAbs) as per protocol in table S2 (see Materials and Methods). This evidence concerns the gene MAPT and tauopathy.