NFKB1 and edema: The research by Lazarini et al. [39] supports our findings on grumixama fruit anti-inflammatory activity by demonstrating the ability of the ethanolic extract to decrease the activation of NF-κB pathway in murine macrophages and reduce the release of TNF-α and the influx of immune cells (neutrophils) to the peritoneal cavity in an in vivo model (mice) of carrageenan-induced paw edema [39].