In the human brain of APOE4 carriers and the induced pluripotent stem cell-based three-dimensional APOE4/4 BBB model, calcineurin-nuclear factor of activated T cells (NFAT) signaling was selectively dysregulated in pericytes, interacting with the APOE promoter and upregulating the APOE protein levels to amyloid accumulation, illustrating the pathogenic effect of APOE4 in cerebral amyloid angiopathy (CAA) [89]. The gene discussed is APOE; the disease is cerebral amyloid angiopathy.