ANGPT2 and Hyperglycemia: Similarly, hyperglycemia induced the overexpression of angiopoietin 2 (Ang2) in endothelial cells, which aggravated apoptosis in pericytes via the integrin receptor in diabetic retinopathy, whereas Ang2 alone did not induce apoptosis under normal glucose[124].Consistent with compromised interpericyte communication by IP-TNTs, a significant reduction in the capillary diameter and capillary blood flow at pericyte locations was detected early after ocular hypertension (OHT) [125].