LRP4 and myasthenia gravis: Myasthenia Gravis (MG) is an autoimmune systemic disorder in which autoantibodies are mainly produced against acetylcholine receptor antibodies (AChR), low-density lipoprotein receptor-related protein 4 (LRP4), or muscle-specific kinase autoantibodies (MuSK) leading to generalized or localized weakened muscular system including ocular, bulbar, and fatigue (Fig. 1) [1-3].