Because eIF4E phosphorylation levels are elevated significantly in the later stages of AD, where they are associated with tau hyper-phosphorylation [56], the mTOR/S6K1-induced suppression of γ-oscillations by oligomeric Aβ1-42 may be instrumental in the cognitive deficits, especially in the early stages of AD. This evidence concerns the gene EIF4E and Alzheimer disease.