Importantly, Ang II in RAS and other thrombotic components such as DABK and Lys-Des-Arg9-BK (DAKD) in the Kallikinase-Kallikin System (KKS) can be degraded by ACE2, but downregulation of ACE2 in COVID-19 can promote thrombosis and increase the risk of myocardial infarction [93]. The gene discussed is ACE2; the disease is myocardial infarction.