The remarkable mitochondrial oxidative damage to cardiomyocytes in patients with chronic kidney disease (CKD) causes mtDNA leakage, which activates the cGAS-STING-NFκB pathway and NFκB-transactivated ornithine decarboxylase (ODC1)-putrescine metabolic flux, inducing cardiac hypertrophy. Here, ODC1 is linked to chronic kidney disease.