Increased TDP43 expression in both oxidized LDL (oxLDL)-treated macrophages and peripheral blood mononuclear cells from patients with coronary artery disease (CAD) can activate inflammation via NF-κB signaling in a cGAS-dependent manner; TDP43 knockout in macrophages significantly alleviated AS progression['\ 40]. The gene discussed is TARDBP; the disease is coronary artery disorder.