Cao et al. ligated the LAD coronary artery of mice to induce MI and found that cGAS-STING consistently and significantly increased the mRNA expression of IFN-stimulated genes (ISGs), including IRF7, IFN-induced protein with tetratricopeptide repeat 1 (IFIT1), IFIT3, chemokine (C-X-C motif) ligand 10 (CXCL10), and cluster of differentiation 14 (CD14). Here, CGAS is linked to myocardial infarction.